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KMID : 0363620070280020185
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 2 p.185 ~ p.199
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Dansam-san (丹蔘散) Inhibits Atherosclerosis through Regulation of Foam Cell Formation and Vascular Smooth Muscle Proliferation
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Ryu Do-Kyun
Choi Dong-Jun
Han Chang-Ho
Jeong Seung-Hyun
Shin Gil-Cho
Lee Won-Chul
Kang Yoon-Ho
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Abstract
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Objective : This study was carried out to investigate the inhibitive effect of a combined-herb prescription of Dansam-san (DSS) on formation of foam cells and cytokine.
Methods : Experimental formation of foam cells was induced on macrophage RAW 264.7 with ox-LDL. The effect of DSS extract was observed by measuring the changes of CD36, $PPAR-{\Gamma}$, MMP-9, iNOS expression and changes of formation level of foam cells after treating experimentally induced foam cells with DSS extract. Then the antioxidative effect of DSS extract was compared with butylated hydroxyanisole (BHA).
Results & Conclusion : Results obtained are as follows: 1. DSS extract showed significant antioxidative effect at 8 mg/ml or more. 2. DSS extract inhibited the formation of foam cells. 3. DSS extract inhibited the creation and revelation of conversion-related material about foam cells. 4. DSS extract prohibited the increase of smooth muscle of vessels.
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KEYWORD
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Dansam-san, foam cells, atherosclerosis
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